ANNUAL REPORT

2019

LETTER FROM THE PRESIDENT

Since the days of Banting and Best, innovative pharmaceutical companies have worked to translate the best available science into beneficial treatments which represent real hope for patients and families impacted by disease and suffering. And today the future of medicines is brighter than ever.

There are more than 500 new medicines currently in development in Canada and 93 per cent of this research is funded by industry. Innovative Medicines Canada’s 40 member companies are working on exciting new treatments—for multiple sclerosis, arthritis, cancer, diabetes, among others—and are using cutting edge research technologies to find new medicines faster and more effectively.

I am extremely proud of the work accomplished by the industry over the course of this difficult year. The regulatory changes to the Patented Medicine Prices Review Board are already being felt by our Canadian companies and affiliates. While the full impact of these changes is not yet known, many companies are reporting delays in launching new products, are downsizing their workforces, and are being forced to put Canadian research projects on hold.

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LETTER FROM THE CHAIR

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In 2019, Innovative Medicines Canada (IMC) and its member companies continued to deliver value to Canadians through the discovery, development and commercialization of life-changing and lifesaving innovative medicines.

Our unwavering commitment to Canadian patients is why we are in this industry. We have seen how new treatments can make a difference in the lives of families; providing a better quality of life for those who suffer from chronic illnesses and giving new hope to those who need it most.

As I reflect on my two years as Chair, it is this commitment to ensuring Canadians have access to the medicines they need that has brought our industry together in the face of the most challenging environment in a generation. Amendments to the Patented Medicines Regulations, which were passed in August, will limit our members’ ability to launch new medicines, conduct clinical trials and make major investments in the Canadian market.

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OVERVIEW

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Innovative Medicines Canada (IMC) is a national association representing 40 innovative pharmaceutical companies. Our members, which range from small Canadian start ups to established global organizations, discover, develop and deliver innovative medicines and vaccines.

As respected partners in Canada’s healthcare systems, our vision is to help all Canadians live longer, healthier lives. Guided by a strict Code of Ethical Practices, IMC works to support its members through effective engagement with stakeholders in the public and private sectors, and governments at the federal, provincial and territorial levels, to advocate for better access to a broad range of ground-breaking new innovative medicines and vaccines. New therapies help Canadians avoid costly hospital stays, invasive surgical procedures, and what can sometimes be a lifetime of dealing with a chronic illness.

Our industry also plays an important role as a driver of innovation in Canada’s life sciences sector. Investments made by our industry not only help scientists discover and develop new treatments and vaccines, they support high-quality jobs and contribute more to our economy. Approximately 10 per cent of industry gross patented medicines revenues are invested into R&D, which totaled more than $19.2-billion in 2016. (Source: EY, 2017)

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A NATIONAL VOICE

EY: DATA ANALYTICS AND MEMBERS’ ECONOMIC FOOTPRINT AND IMPACT IN CANADA, OCTOBER 2017

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Healthcare is a shared responsibility in Canada, with both federal and provincial/territorial governments playing distinct roles in the regulation, approval and delivery of innovative medicines. IMC represents its members at both the federal and provincial/territorial levels, with its headquarters in Ottawa and regional directors and membership-driven teams representing five regions: Atlantic, Quebec, Ontario, Prairies and British Columbia.

In Ottawa, IMC engages with the federal government and national stakeholders including patient advocacy organizations and health charities, life sciences and health research organizations and business groups, to support policies that improve Canada’s regulatory environment, increase access to innovative medicines and ensure the effective protection of intellectual property.

At the regional level, IMC works to support its members through effective engagement with provincial/territorial governments and stakeholders, including patient advocacy organizations and health charities, regional life sciences organizations and regional chambers of commerce and business organizations. IMC also actively engages with the Council of the Federation to advocate for policies that improve patients’ access to a broad range of medicines and to raise awareness about the industry’s role as a driver of economic growth.

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THE VALUE
OF MEDICINES

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New medicines deliver extraordinary value to individual Canadians, our healthcare institutions and overall health systems. They prevent or cure disease, extend lives, relieve suffering and improve an individual’s quality of life.

Advances in new medicines have significantly increased Canadians chances of survival. For example, more than 66 per cent of people diagnosed with cancer today survive five years and longer, compared to 33 per cent in 1964. Approximately 83 per cent of these survival gains can be attributed to new treatments. In addition, the introduction of highly active anti-retroviral therapy (HAART) combinations in 1996 has transformed an HIV diagnosis from a death sentence to a treatable chronic disease in a single generation. A 20-year old diagnosed with HIV today can expect to live into his or her 70’s. Dramatic declines in death rates did not occur with one single breakthrough drug, but rather a series of advances providing important treatment options for patients over time.

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INVESTING IN INNOVATION

The innovative pharmaceutical sector in Canada is one of incredible promise. It is a sector that makes invaluable contributions not only to Canada’s economy, but also to the health of Canadians.

The discovery, development and delivery of new medicines is a decades-long process, involving many failures as stepping stones to breakthrough discoveries and investments in the billions. Canada’s innovative pharmaceutical companies are currently the third largest R&D funder in the country and 20 of our members are among the top 100 corporate R&D spenders. With more than $1-billion spent in R&D every year (10 per cent of revenues), our members work tirelessly toward discovering the next innovative treatment. They are also fueling Canada’s knowledge-based economy by generating over $19.2-billion in economic activity (Source: EY 2017).

Canada is home to some of the best researchers, scientists and research infrastructure in the world. With more than 500 new therapies currently in development, our member companies partner with universities and research centres across the country, including the Ontario Institute for Cancer Research, adMare BioInnovations and Toronto Acceleration Partners, to leverage their expertise and push the boundaries of medical innovation. This growing network of partnerships and collaboration represents tens of thousands of jobs and significant investments, including $2.5-billion in hospitals and universities, over the past two decades.

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A PARTNER FOR PATIENTS

The innovative pharmaceutical industry and patient organizations are both tremendously passionate about keeping Canadians healthy and productive. Innovative Medicines Canada (IMC) members support, and often partner with, patient organizations and health charities on initiatives that facilitate research, generate awareness, and create educational programs that help patients better understand their treatments.

Patients are at the heart of our healthcare systems and their engagement is critical across the life cycle of a medicine. Patient groups play a vital role in sharing knowledge as equal and valued partners with pharmaceutical companies. They share valuable information and experiences concerning their diseases and conditions. Our member companies use this insight to inform medical research and to develop more patient-centered treatments. The collaboration between patient groups and pharmaceutical companies is key to ensuring patients have a voice in the development of the treatments.

IMC also supports the shared objective of promoting access to innovative medicines for all Canadians. Our partners include: Best Medicines Coalition (BMC), Health Charities Coalition of Canada (HCCC), Canadian Organization for Rare Disorders (CORD), Neurological Health Charities Canada (NHCC) and Canadian Cancer Survivor Network (CCSN).

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A PARTNER FOR PATIENTS

HEALTH PARTNERS INTERNATIONAL OF CANADA

Nearly a third of the world’s population does not have access to basic healthcare. This problem is particularly prominent in the developing world.

Founded in 1990 by several Innovative Medicines Canada (IMC) member companies, Health Partners International of Canada (HPIC) is a Canadian registered charity dedicated to increasing access to medicine and improving health for the most vulnerable people in the world. Today, Canada’s pharmaceutical and healthcare industry works with HPIC to treat about 1 million people every year through HPIC’s Canadian volunteer and global humanitarian network.

HPIC equips medical mission teams with medicines and stocks clinics and hospitals in impoverished communities. They also mobilize medical relief during emergencies and help to strengthen build the capacity of local health systems.

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HEALTH PARTNERS INTERNATIONAL OF CANADA

A CHALLENGING
REGULATORY ENVIRONMENT

On August 21, the federal government published new regulations that will profoundly change the future of the pharmaceutical industry in Canada. Through amendments to the Patented Medicines Regulations, the federal government has put forward a number of changes that will limit Canadian patients’ access to new innovative medicines and discourage investment in Canada’s life sciences sector for years to come.

The Patented Medicines Regulations govern the activities of the Patented Medicine Prices Review Board (PMPRB), an arms’ length government agency charged with setting the maximum price that can be charged for patented medicines in Canada, otherwise known as a ceiling price.

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A CHALLENGING REGULATORY ENVIRONMENT

FOCUS ON PHARMACARE

Pharmacare as a national program holds tremendous promise in helping Canadians access the medicines they need. Under the umbrella of national pharmacare, the federal government has committed to work with its partners on the creation of:

  • The Canadian Drug Agency, a new national drug agency that would build on existing provincial and territorial successes, and take a coordinated approach to assessing effectiveness and negotiating prescription drug prices on behalf of Canadians.
  • A national formulary—a comprehensive, evidence-based list of prescribed drugs, to be developed as part of the Canadian Drug Agency as the basis for a consistent approach to formulary listing and patient access across the country.
  • A national strategy for high-cost drugs for rare diseases to help Canadians get better access to the effective treatments they need.

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Focus on Pharmacare

OUR COMMITMENT TO ETHICS

Trust and confidence are key to building strong, productive and mutually beneficial relationships.

Innovative Medicines Canada (IMC) and its members have set a high standard for ethical, transparent and open practices that respect the relationships among our member company employees, the life sciences sector, healthcare professionals and the Canadian public.

CODE OF ETHICAL PRACTICES

Since 1988, the Code of Ethical Practices (the “Code”) has been a tangible demonstration of IMC’s commitment to a relationship based on trust, openness and transparency with healthcare providers. It establishes clear guidelines to ensure the health and well-being of Canadians is always our first priority.

All members of IMC are bound by the association’s Code, which maintains strict standards on what is acceptable in our work with the wider healthcare community.

A GLOBAL COMMITMENT TO ETHICS

IMC is a member of the International Federation of Pharmaceutical Manufactures & Associations (IFPMA) and adheres to the IFPMA Ethos—the foundation which shapes how the research-based biopharmaceutical industry sustains trust based on the core values of care, fairness, respect and honesty.

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Our Commitment to Ethics

THE HEALTH
RESEARCH FOUNDATION

The Health Research Foundation (HRF) of Innovative Medicines Canada was established in 1964 to support and increase the capacity for clinical research in Canada. During the early years of the Foundation, many types of grants were given, including research grants, and. Through its 55 years, the HRF has remained a non-profit organization whose mission is to support health research in Canadian academic health centers and promote the value of health research in Canada. The HRF, in collaboration with the Canadian Institutes of Health Research, has provided over $30-million in funding to more than 1,700 researchers across Canada. An annual highlight for the HRF is the selection and presentation of the Medal of Honour. The award is presented to a truly outstanding individual whose research and contribution to public policies supportive of research and development in Canada have achieved international recognition. Throughout the years, recipients have made a notable contribution to the advancement of knowledge in the health sciences and the improvement of healthcare in Canada. Past winners have included: Sir Alexander Fleming, for the discovery of penicillin; Dr. Charles H. Best, for the co-discovery of insulin; Dr. Wilder Graves Penfield, for contributions to neurological sciences; and Dr. Julio Montaner, for life changing contributions to the field of HIV/AIDS, including the development of Highly Active Antiretroviral and Treatment as Prevention Therapies.

In 2019, the HRF turned its focus to supporting research in the emerging field of Artificial Intelligence (AI). The Foundation believes AI will play an important role in the future of health research in Canada. Industry, government and stakeholder partnerships within this sector can make a positive impact on Canada’s health systems as life sciences research becomes increasingly driven by AI platforms, tools and systems. From hospital care to clinical research, drug development and insurance, AI has the potential to revolutionize health systems efficiencies and improve patient outcomes while attracting foreign investment to Canada.

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The Health Research Foundation

MAINTAINING A VIBRANT
PRIVATE PAYERS MARKET

More than 24 million Canadians depend on access to medicines and vaccines through employer-sponsored private plans. Private plans provide coverage to an active working population and their dependents and ensure that their members have timely access to the medicines they need to get back to work as quickly as possible.

Innovative Medicines Canada (IMC) believes it is essential for optimal workplace health and productivity that employees and their families have access to medicines and services. That is why IMC and its member companies meet regularly with private market stakeholders to listen to their concerns, share ideas and talk about the value of access to affordable care.

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Maintaining a Vibrant Private Payers Market

OUR STRATEGIC PLAN

In 2019, Innovative Medicines Canada (IMC) launched a new strategic plan to guide the association’s activities over a three-year period marked by significant challenges and change for the industry in Canada.

This plan is supported by our vision: A future in which all Canadians are living healthy and longer lives through sustainable access to innovative medicines and vaccines. As the voice of Canada’s research-based pharmaceutical companies, it is the association’s mission to promote and support the policies that enable the discovery, development and commercialization of innovative medicines and vaccines that enhance the lives of all Canadians.

Guided by this vision and mission, IMC has identified four strategic pillars which will shape the association’s priorities from 2019 to 2021:

  1. Optimal regulatory environment: A globally competitive, patient-oriented, modern and innovation-friendly regulatory environment in Canada.
  2. High-performing health systems: Solutions to improve health systems effectiveness and patient access.
  3. Data driven policy: Policies, shaped through credible data, that recognize the value of the industry to patients, health systems and the economy.
  4. Respected partner: Enhanced credibility of the industry through impactful relationships, proactive communication, and ethics.

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Our strategic plan

YEAR 1 IN REVIEW

OPTIMAL REGULATORY ENVIRONMENT

The objective for the first pillar of the strategic plan is to ensure Canada has a regulatory system that is globally competitive, patient-oriented, modern, and innovation-friendly.

PMPRB

On PMPRB, the association’s objective for 2019 was to ensure the best possible outcome for the industry and future sustainability of the sector. This saw the industry working in close collaboration with a wide cross-section of stakeholders from the life sciences, patient advocacy and business communities, as well as with provincial governments to raise awareness about the significant negative consequences that would result from the regulatory changes, as proposed.

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Year 1 in Review

OUTLOOK FOR 2020

As the association enters the second year of its strategic plan, it will continue to drive towards its objectives. IMC will advocate for patient centric solutions that promote access to medicines, and a regulatory environment that fosters innovation in Canada’s life sciences sector.

In advance of IMC’s Annual General Meeting in late 2019, the Board of Directors approved modifications to IMC’s strategic objectives to reflect the emerging issue of U.S. importation of drugs from Canada and the important policy work underway in the rare diseases space.

The coming year will continue to be one of change, as the industry adjusts to a shifting regulatory environment and policies related to national pharmacare continues to evolve.

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Outlook for 2020

OUR MEMBERS

IMC Member Companies

Akcea
Biovectra
Bristol Myerss Quibb
Ceapro
CCPE
EMD
Endoceutics
Gsk
Kalgene
Knight Therapeutics
Medicago
Otsuka
Paladin
Pfizer
Purdue
Ropack
Sunovion
Thera technologies
Vantage

2019 IMC Board of Directors

CHAIR

Ronnie Miller, Hoffmann-La Roche Limited

Vice-Chair

Al Reba, Bristol-Myers Squibb Canada

Treasurer

Jared Rhines, Akcea Therapeutics Canada Inc.

Jorge Bartolome, Janssen Inc.

Frédéric Fasano, Servier Canada Inc.

John Haslam, Horizon Therapeutics Canada Inc.

Alok Kanti, Bayer Inc.

Stéphane Lassignardie, AbbVie Corporation

Lisa Matar, Eli Lilly Canada Inc.

Michael Mullette, Sanofi Canada

Sylvie Pilon, Lundbeck Canada Inc.

Anna van Acker, Merck Canada Inc.